https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Genome-wide association analysis of young-onset stroke identifies a locus on chromosome 10q25 near HABP2 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:24389 -6 and performed in silico association analyses in an independent sample of ≤1003 cases and 7745 controls. Results: One stroke susceptibility locus at 10q25 reached genome-wide significance in the combined analysis of all samples from the discovery and follow-up stages (rs11196288; odds ratio =1.41; P=9.5x10-9). The associated locus is in an intergenic region between TCF7L2 and HABP2. In a further analysis in an independent sample, we found that 2 single nucleotide polymorphisms in high linkage disequilibrium with rs11196288 were significantly associated with total plasma factor VII.activating protease levels, a product of HABP2. Conclusions: HABP2, which encodes an extracellular serine protease involved in coagulation, fibrinolysis, and inflammatory pathways, may be a genetic susceptibility locus for early-onset stroke.]]> Wed 15 Dec 2021 16:09:44 AEDT ]]> A novel MMP12 locus Is associated with large artery atherosclerotic stroke using a genome-wide age-at-onset informed approach https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:16959 -7), with independent replication in a second population (p = 0.0048, OR(95% CI) = 1.18(1.05–1.32); meta-analysis p = 2.6×10-8). The nearby gene, MMP12, was significantly over expressed in carotid plaques compared to atherosclerosis-free control arteries (p = 1.2×10-15; fold change = 335.6). Permutation analyses demonstrated improved significance for associations when accounting for age-at-onset in all four stroke phenotypes (p<0.001). Our results show that a covariate-informed design, by adjusting for age-at-onset of stroke, can detect variants not identified by conventional GWAS.]]> Wed 11 Apr 2018 17:21:31 AEST ]]> Upconversion Nanoparticle-Based Cell Membrane-Coated cRGD Peptide Bioorthogonally Labeled Nanoplatform for Glioblastoma Treatment https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:52094 Thu 28 Sep 2023 14:28:30 AEST ]]> Low-frequency and common genetic variation in ischemic stroke: the METASTROKE collaboration https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:25883 Sat 24 Mar 2018 07:25:54 AEDT ]]> What Do They Capture? - A Structural Analysis of Pre-Trained Language Models for Source Code https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:47308 Fri 13 Jan 2023 10:59:31 AEDT ]]>